CD45存在于除红
细胞和浆细胞以外的所有血细胞。它在T,B细胞上的不同作用是因为不同的CD45RA, CD45RB, CD45RC, CD45RAB, CD45RAC, CD45RBC, CD45R0, CD45R (ABC) 这些Isoform导致的这里又段文献,描述的很详细了CD45RA is located on naive T cells and CD45R0 is located on memory T cells. CD45 is also highly glycosylated. CD45R is the longest protein and migrates at 200 kDa when isolated from T cells. B cells also express CD45R with heavier glycosylation, bringing the molecular weight to 220 kDa, hence the name B220B cell isoform of 220 kDa. B220 expression is not restricted to B cells and can also be expressed on activated T cells, on a subset of dendritic cells and other antigen presenting cells.Naive T lymphocytes express large CD45 isoforms and are usually positive for CD45RA. Activated and memory T lymphocytes express the shortest CD45 isoform, CD45R0, which lacks RA, RB and RC exons. This shortest isoform facilitates T cell activation.The cytoplasmic domain of CD45 is one of the largest known and it has an intrinsic phosphatase activity that removes an inhibitory phosphate group on a tyrosine kinase called Lck (in T cells) or Lyn/Fyn/Lck (in B cells) and activates it.【B细胞性小
淋巴细胞性
淋巴瘤】可表现为淋巴瘤或白血病。肿瘤特征表现为单一形态的小淋巴细胞浸润,但会有灶性大细胞(假滤泡或增殖中心)出现。偶尔可以向浆细胞分化。
从该报告来看,仍无法明确诊断具体的B细胞恶性淋巴瘤的类型。从染色结果分析,CD3(-)只能排除T细胞肿瘤可能,CD20(++)很多淋巴瘤都可以,比较常见的包括霍奇金淋巴瘤(结节性淋巴细胞为主型),以及非霍奇金淋巴瘤(小淋巴细胞性淋巴瘤)。NSE(-)排除神经内分泌肿瘤,如PNET。建议
到三级进一步进行病理会诊,加作免疫组化染色指标CD5/CD23/CD79a/
在明确诊断后再寻求进一步化疗方案