silvermetcream是什么意思

silver met cream

银见霜

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MET也称c-Met或肝细胞生L因子（Hepatocyte Growth Factor，HFG）受体，是一种络氨酸激酶（Tyrosine kinase）。MET一般在上皮细胞组织表达。MET的激活机制有多种，比如过度表达、基因扩增、基因变异、自源性或旁源性的HGF激活等。有肿瘤遗传学证据表明MET的变异可以致癌，且多见于多发性髓样瘤和脑胶质瘤。抑制ME T可以抗癌有间接的临床证据。比如辉瑞的Crizotinib是ALK抑制剂，2011年获得FDA批准用于治疗ALK激活变异的非小细胞肺癌，Crizotinib同时也是MET抑制剂，相信其抗癌效果与同时抑制MET有关。BMS/Exelixis的Cabozantinib也同时抑制MET和VEGFR2，在2012年获得FDA批准用于治疗甲状腺癌。另外，许多TKI耐药的病人呈现MET激活，也间接地支持MET作为一个有效的抗癌分子靶点。

MET抑制剂作为抗癌药的开发也会有很多挑战。如果MET激活是由基因扩增造成，抑制MET蛋白可能进一步激活其基因的表达，产生更多的MET。真是野火扑不尽，随风吹又生。第二个难点是尚无有效的生物标记物去确定MET过度表达的适应人群。目前的MET抑制剂主要用于治疗非小细胞肺癌、乳腺癌、食道癌、前列腺癌、甲状腺癌等。因为HFG是到目前为止唯一已知的MET配体，抗HGF的单克隆抗体也可以抑制MET的信号传导。虽然和抗EGFR单抗或小分子EGFR抑制剂相比MET抑制剂的开发至少慢了十年，但以往EGFR抑制剂的临床经验将有助于MET抑制剂和抗HGF单抗的成功开发。处于临床开发阶段的小分子MET抑制剂有GSK-1363089（GSK、Exelixis）、ARQ197（ArQule）、JNJ-38877605（强生）、BMS-777607（施贵宝）、MK-2461（默克）、E7050（Eisai）、PF-02341066/PF-04217903（辉瑞）、AMG-458（安进）等，抗HGF单抗包括Onartuzumab（基因泰克）、TAK701（Takeda）、Ficlatuzumab（AVEO）和Rilotumumab（安进）等。无论如何，目前证据表明MET应该是一个不错的抗癌分子靶点。

歌曲名:Silver And Gold

歌手:Dolly Parton

专辑:Original Album Classics

Title:Silver And Gold

Dolly Parton

Well, I met an old man walkin' down the street

His clothes were torn and tattered

With sandals on his feet

And I stopped to help him

And lend him a hand

He said, I love you so much

But you must understand

Silver and gold might buy you a home

But things of this world

They won't last you long

And time has a way of turning us old

And time can't be bought back with silver and gold

And he said to me, let's rest for awhile

For I have some good news to share with you, child

He said, you can't change this old world

The people need to know

That a dear savior died here

A long, long time ago ,and

Silver and gold might buy you a home

But things of this world

They won't last you long

And time has a way of turning us old

And time can't be bought back with silver and gold

His eyes shown like diamonds

And his smile was heaven sent

His hair was long and flowing

And his back was slightly bent

And I knew he knew it

For that day I changed

And I watched him walk on

I forgot to get his name

He said, silver and gold can't buy you a home

When this life has ended

And your time is gone

But you can live in a world where

You'll never grow old

And things can't be bought there with silver and gold

And time can't be bought back with silver and gold

http://music.baidu.com/song/10290065

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